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CAS No. 21829-25-4 | Nifedipine

Name: Nifedipine CAS No. 21829-25-4 MF:C17H18N2O6 MW:346.33 Purity:98% Package: 10g,25g,50g,100g,250g Worldwide Delivery

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Biochemicals

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Product introduction

Introduction and application of CAS No. 21829-25-4 | Nifedipine

Synonyms:1,4-Dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylicaciddimethyl;

Nifedipine,1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddimethylester;

Nifedipine(125mg);

Niterbenzenehorizontal;

1,4-dihydro-2,6-diMethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate;

ALDIPINANIFED;

ADALATE;

4-(2'-NITROPHENYL)-2,6-DIMETHYL-3,5-DICARBOMETHOXY-1,4-DIHYDROPYRIDINE

Specification:

ITEMS	SPECIFICATION
CAS	21829-25-4
MF	C17H18N2O6
MW	346.33
Melting point	171-175 °C
Boiling point	481.08°C
Density	1.2109
Acidity coefficient	pKa -0.9/>13
Color	Sticky yellow
Solubility	Soluble in DMSO
Form	Powder
Storage condition	2-8°C

Pharmacological effects:

Nifedipine, also known as cardiotide, rixinpine, and nifedipine, is a dihydropyridine calcium antagonist that can inhibit the uptake of Ca2+ by myocardium and vascular smooth muscle, dilate coronary arteries, increase coronary blood flow, and increase myocardial response to Ischemia tolerance can also dilate peripheral arterioles, reduce peripheral vascular resistance, relieve coronary artery spasm, increase coronary flow, improve myocardial hypoxia, and thereby reduce blood pressure. It does not affect blood pressure when dilating coronary arteries in small doses, making it a better anti-angina drug. It is used to prevent and treat angina pectoris caused by coronary heart disease without adverse effects on respiratory function. It is especially effective for angina pectoris caused by coronary artery spasm and angina pectoris caused by respiratory obstructive diseases. Its efficacy is better than that of β-blockers. It is also suitable for various types of hypertension, including severe and resistant hypertension. This product can be taken for a long time in the treatment of refractory congestive heart failure. It is also used to treat primary pulmonary hypertension, diffuse esophageal spasm, bronchial asthma, duodenal ulcer, urethral obstruction, exercise-induced asthma, achalasia, etc. Nifedipine has certain selectivity for vascular smooth muscle and has weak direct negative inotropic and degenerative effects on the heart. Therefore, systemic administration does not cause a slowdown in heart rate but a reflex increase in heart rate.

Chemical properties:

yellow crystal. Melting point 172-174℃. Easily soluble in acetone, chloroform, ethyl acetate, soluble in hot methanol, insoluble in water. Easily deteriorates when exposed to light.

Purpose:

Long-acting coronary vasodilator. This product can increase coronary blood flow and reduce myocardial oxygen consumption. It is used for acute and chronic coronary insufficiency, especially angina pectoris and myocardial infarction. Purpose: Used to treat various acute and chronic coronary insufficiency, angina pectoris and other diseases.

Production method:

o-nitrobenzaldehyde, methyl acetoacetate, methanol and ammonia are refluxed together, then frozen, crystallized and filtered to obtain crude nifedipine. The crude product is recrystallized with methanol to obtain the finished product, with a yield of 50%.

Package and transportation :

Package: 10g,25g,50g,100g,250g